Integration Point: Response - Continuous Outcome
Gabriel Potvin
August 07, 2025
IntegrationPointResponseContinuous.RmdGo back to the Integration Point: Response page
This integration point and outcome is currently available for the Two Arm Confirmatory and Multiple Arm Confirmatory Study Objectives.
Input Variables
When creating a custom R script, you can optionally use specific
variables provided by East Horizon’s engine itself. These variables are
automatically available and do not need to be set by the user, except
for the UserParam variable. Refer to the table below for
the variables that are available for this integration point and
outcome.
| Variable | Type | Description |
|---|---|---|
| NumSub | Integer | Number of subjects in the trial. |
| TreatmentID | Vector of Integer | Vector of length NumSub, indicating the allocation of
subjects to arms. Index 0 represents placebo/control. For
example, [0, 0, 1] indicates three subjects: two in the
control group and one experimental. |
| Mean | Vector of Numeric | Vector of length equal to the number of arms, indicating the mean of the treatments. |
| StdDev | Vector of Numeric | Vector of length equal to the number of arms, indicating the standard deviation of the treatments. |
| UserParam | List | Contains all user-defined parameters specified in the East Horizon
interface (refer to the Instructions
section). To access these parameters in your R code, use the syntax:
UserParam$NameOfTheVariable, replacing
NameOfTheVariable with the appropriate parameter name. |
Expected Output Variable
East Horizon expects an output of a specific type. Refer to the table below for the expected output for this integration point:
| Type | Description |
|---|---|
| List | A named list containing Response and
ErrorCode. |
Expected Members of the Output List
| Members | Type | Description |
|---|---|---|
| Response | Vector of Double | Vector of length NumSub, containing the generated
responses for all subjects. |
| ErrorCode | Integer | Optional. Can be used to handle errors in your script: – 0: No error.– Positive Integer: Nonfatal
error, the current simulation will be aborted, but the next simulation
will proceed.– Negative Integer: Fatal error, no
further simulations will be attempted. |
Minimal Template
Your R script could contain a function such as this one, with a name
of your choice. All input variables must be declared, even if they are
not used in the script. We recommend always declaring
UserParam as a default NULL value in the
function arguments, as this will ensure that the same function will work
regardless of whether the user has specified any custom parameters in
East Horizon.
GenerateResponse <- function( NumSub, TreatmentID, Mean, StdDev, UserParam = NULL )
{
nError <- 0 # Error handling (no error)
vPatientOutcome <- rep( 0, NumSub ) # Initializing response array to 0
# Write the actual code here.
# Store the generated continuous response values in a vector called vPatientOutcome.
return( list( Response = as.double( vPatientOutcome ), ErrorCode = as.integer( nError ) ) )
}A detailed template with step-by-step explanations is available here: SimulatePatientOutcome.Continuous.R